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KMID : 0357319940290050421
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Journal of the Korean Society for Microbiology
1994 Volume.29 No. 5 p.421 ~ p.438
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Chemotherapy of Helicobacter pylori Infection
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박철근
초휴진/윤희상/이우곤/조명제/강경희/백승철/이광호
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Abstract
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Helicobacter pylori is the causative agent of type B chronic gastritis and increases an individual risk of the development of stomach cancer. In this study, we aimed to design an appropriate therapeutic modality for Helicobacter pylori infection
and to
obtain Helicobacter pylori negative biopsy specimens from competely cured gastric mucosa. One hundred ninty volunteers received 6-weeks course of triple chemotherapy with tripotassium dicitrato bismuthate, amoxicillin and metronidazole and were
subjected to endoscopic follow-up 2-4 weeks after chemotherapy. Biopsy specimens taken from the gastric antrum and duodenum were tested for Helicobacter pylori colonization by bacterial culture, urease test, and polymerase chain rcaction, Of 90
volunteers who had been Helicobacter pylori-positive before treatment, 38(42.2%) were converted to Helicobacter pylori-negative in follow-up endoscopy. There was no significant difference in negative conversion rates between adults(37.8%) and
children(46.7%). Thirty volunteers who failed in eradication of Helicobacter pylori in 6-weeks triple chemotherapy were retreated with additonal 6-weeks chemotherapy. The negative conversion rate after additonal therapy was 53.3%. In another
volunteers
group, 19 volunteers were treated with double dose of original triple chemotherapy for 6 weeks. Of 12 volunteers who had been Helicobacter pylori-positive before treatment, 7(58.3%) were converted to Helicobacter pylori-negative in follow-up
endoscopy.
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KEYWORD
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